TY  - Journal 
T1  - Nanomaterials for Deep Tumor Treatment
JO  - Mini-Reviews in Medicinal Chemistry
VL  - 21
IS  - 6
SP  - 677
EP  - 688
PY  - 2021
T2  - 
AU  - Daria  Yu.  Kirsanova*
AU  - Zaira  M.  Gadzhimagomedova
AU  - Aleksey  Yu.  Maksimov and   Alexander  V.  Soldatov
SN  - 1389-5575/1875-5607
DO  - http://dx.doi.org/10.2174/1389557520666201111161705
UR  - http://www.eurekaselect.com/node/187862/article
KW  - X-ray photodynamic therapy
KW  - photodynamic therapy
KW  - cancer treatment
KW  - photosensitizer
KW  - nanoparticle
KW  - scintillator
KW  - nanomaterials
KW  - reactive oxygen species.
AB  - According to statistics, cancer is the second leading cause of death in the world. Thus, it is
important to solve this medical and social problem by developing new effective methods for cancer
treatment. An alternative to more well-known approaches, such as radiotherapy and chemotherapy, is
photodynamic therapy (PDT), which is limited to the shallow tissue penetration (< 1 cm) of visible
light. Since the PDT process can be initiated in deep tissues by X-ray irradiation (X-ray induced PDT,
or XPDT), it has a great potential to treat tumors in internal organs. The article discusses the principles
of therapies. The main focus is on various nanoparticles used with or without photosensitizers,
which allow the conversion of X-ray irradiation into UV-visible light. Much attention is given to the
synthesis of nanoparticles and analysis of their characteristics, such as size and spectral features. The
results of in vitro and in vivo experiments are also discussed.
ER  -